In this presentation we discuss the SAFT force field for molecular simulation of fluids. In this approach, a molecular-based equation of state is used to obtain coarse-grained intermolecular potentials that can then be employed in molecular simulation over a wide range of thermodynamic conditions. The macroscopic experimental data for the vapor−liquid equilibria (saturated liquid density and vapor pressure) of a given system are represented with the equation of state and used to estimate effective intermolecular parameters. This methodology allows for a reliable representation of the fluid-phase equilibria (for which the model was parametrized), as well as an accurate prediction of other properties such as the interfacial tension and transport properties of complex fluids, polymers, asphaltenes and mixtures.